![Anti-CLDN1 antibody (112-211) [S1MR] (STJ11101351)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/90264/359418/STJ11101351__2__37683.1713123866.jpg?c=1 "Anti-CLDN1 antibody (112-211) [S1MR] (STJ11101351)")
Anti-CLDN1 antibody (112-211) [S1MR] (STJ11101351)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Claudin 1 (112-211) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S1MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:2000-1:12000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLDN1 |
| Gene ID | 9076 |
| Uniprot ID | CLD1_HUMAN |
| Immunogen Region | 112-211 |
| Immunogen Sequence | EVQKMRMAVIGGAIFLLAGL AILVATAWYGNRIVQEFYDP MTPVNARYEFGQALFTGWAA ASLCLLGGALLCCSCPRKTT SYPTPRPYPKPAPSSGKDYV |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 112-211 of human Claudin 1 (O95832). |
Additional Info
| Tissue Specificity | Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. |
| Function | Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions. (Microbial infection) Acts as a co-receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell. Acts as a receptor for dengue virus. |
| Protein Name | Claudin-1Senescence-Associated Epithelial Membrane Protein |
| Database Links | Reactome: R-HSA-420029 |
| Cellular Localisation | Cell JunctionTight JunctionCell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneAssociates With Cd81 And The Cldn1-Cd81 Complex Localizes To The Basolateral Cell Membrane |
| Alternative Antibody Names | Anti-Claudin-1 antibodyAnti-Senescence-Associated Epithelial Membrane Protein antibodyAnti-CLDN1 antibodyAnti-CLD1 antibodyAnti-SEMP1 antibodyAnti-UNQ481 antibodyAnti-PRO944 antibody |
Information sourced from Uniprot.org