Anti-CLCNKB antibody (STJ190691)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Chloride channel protein ClC-Kb for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLCNKB |
| Gene ID | 1188 |
| Uniprot ID | CLCKB_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | CLCKB Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Anion-selective channel permeable to small monovalent anions with ion selectivity for chloride > bromide > nitrate > iodide. Forms a homodimeric channel where each subunit has its own ion conduction pathway. May conduct double-barreled currents controlled by two types of gates, two fast gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Assembles with the regulatory subunit BSND/Barttin for sorting at the basolateral plasma membrane domain and functional switch to the ion conducting state. CLCNKB:BSND channels display mostly a linear current-voltage relationship controlled by common gate. Mediates chloride conductance along nephron segments, namely the thick ascending limb of Henle's loop, convoluted tubule and the collecting duct, contributing to the maintenance of systemic acid-base and electrolyte homeostasis. Conducts chloride currents in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing. |
| Protein Name | Chloride Channel Protein Clc-KbChloride Channel KbClc-K2 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Chloride Channel Protein Clc-Kb antibodyAnti-Chloride Channel Kb antibodyAnti-Clc-K2 antibodyAnti-CLCNKB antibody |
Information sourced from Uniprot.org