Anti-CLCN7 antibody (626-805) (STJ28966)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CLCN7 (626-805) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLCN7 |
| Gene ID | 1186 |
| Uniprot ID | CLCN7_HUMAN |
| Immunogen Region | 626-805 |
| Immunogen Sequence | TAREVMSTPVTCLRRREKVG VIVDVLSDTASNHNGFPVVE HADDTQPARLQGLILRSQLI VLLKHKVFVERSNLGLVQRR LRLKDFRDAYPRFPPIQSIH VSQDERECTMDLSEFMNPSP YTVPQEASLPRVFKLFRALG LRHLVVVDNRNQVVGLVTRK DLARYRLGKRGLEELSLAQT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 626-805 of human CLCN7 (NP_001278.1). |
Additional Info
| Tissue Specificity | Brain and kidney. |
| Function | Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. |
| Protein Name | H(+/Cl(- Exchange Transporter 7Chloride Channel 7 Alpha SubunitChloride Channel Protein 7Clc-7 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Lysosome MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-H(+/Cl(- Exchange Transporter 7 antibodyAnti-Chloride Channel 7 Alpha Subunit antibodyAnti-Chloride Channel Protein 7 antibodyAnti-Clc-7 antibodyAnti-CLCN7 antibody |
Information sourced from Uniprot.org