Anti-CLCN6 antibody (Cytoplasmic Domain) (STJ13100869)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from the cytoplasmic domain of human CLCN6 conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-CLCN6 (Cytoplasmic Domain) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | CLCN6 |
| Gene ID | 1185 |
| Uniprot ID | CLCN6_HUMAN |
| Immunogen | A synthetic peptide from the cytoplasmic domain of human CLCN6 conjugated to blue carrier protein was used as the antigen. |
| Immunogen Region | Cytoplasmic Domain |
| Specificity | Specific for CLCN6. |
Additional Info
| Post Translational Modifications | N-glycosylated on several asparagine residues. |
| Function | Voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the late endosome lumen. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. |
| Protein Name | H(+/Cl(- Exchange Transporter 6Chloride Channel Protein 6Clc-6Chloride Transport Protein 6 |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-6802952 |
| Cellular Localisation | Late Endosome MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-H(+/Cl(- Exchange Transporter 6 antibodyAnti-Chloride Channel Protein 6 antibodyAnti-Clc-6 antibodyAnti-Chloride Transport Protein 6 antibodyAnti-CLCN6 antibodyAnti-KIAA0046 antibody |
Information sourced from Uniprot.org