| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-H+/Cl-exchange transporter 6 (611-660 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 ELISA 1:40000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CLCN6 |
| Gene ID: | 1185 |
| Uniprot ID: | CLCN6_HUMAN |
| Immunogen Region: | 611-660 aa |
| Specificity: | CLC-6 Polyclonal Antibody detects endogenous levels of CLC-6 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human CLCN6 at the amino acid range 611-660 |
| Post Translational Modifications | N-glycosylated on several asparagine residues. |
| Function | Voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the late endosome lumen. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. |
| Protein Name | H(+/Cl(- Exchange Transporter 6 Chloride Channel Protein 6 Clc-6 Chloride Transport Protein 6 |
| Database Links | Reactome: R-HSA-2672351 Reactome: R-HSA-6802952 |
| Cellular Localisation | Late Endosome Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-H(+/Cl(- Exchange Transporter 6 antibody Anti-Chloride Channel Protein 6 antibody Anti-Clc-6 antibody Anti-Chloride Transport Protein 6 antibody Anti-CLCN6 antibody Anti-KIAA0046 antibody |
Information sourced from Uniprot.org
