Anti-CLCN5 antibody (STJ13100104)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from mouse CLCN5 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and human.
General Information
| Short Description | Rabbit polyclonal anti-CLCN5 for use in IHC and WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:1000 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | CLCN5 |
| Gene ID | 1184 |
| Uniprot ID | CLCN5_HUMAN |
| Immunogen | A synthetic peptide from mouse CLCN5 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and human. |
| Specificity | Specific for CLCN5. |
Additional Info
| Post Translational Modifications | Ubiquitinated by NEDD4L in the presence of albumin.which promotes endocytosis and proteasomal degradation. |
| Function | Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable). |
| Protein Name | H(+/Cl(- Exchange Transporter 5Chloride Channel Protein 5Clc-5Chloride Transporter Clc-5 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Golgi Apparatus MembraneMulti-Pass Membrane ProteinEndosome MembraneCell Membrane |
| Alternative Antibody Names | Anti-H(+/Cl(- Exchange Transporter 5 antibodyAnti-Chloride Channel Protein 5 antibodyAnti-Clc-5 antibodyAnti-Chloride Transporter Clc-5 antibodyAnti-CLCN5 antibodyAnti-CLCK2 antibody |
Information sourced from Uniprot.org