| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CLCN5 (637-816) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLCN5 |
| Gene ID: |
1184 |
| Uniprot ID: |
CLCN5_HUMAN |
| Immunogen Region: |
637-816 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 637-816 of human CLCN5 (NP_001121370.1). |
| Immunogen Sequence: |
YPFLEAKEEFAHKTLAMDVM KPRRNDPLLTVLTQDSMTVE DVETIISETTYSGFPVVVSR ESQRLVGFVLRRDLIISIEN ARKKQDGVVSTSIIYFTEHS PPLPPYTPPTLKLRNILDLS PFTVTDLTPMEIVVDIFRKL GLRQCLVTHNGRLLGIITKK DVLKHIAQMANQDPDSILFN |
| Tissue Specificity | Kidney. Moderately expressed in aortic vascular smooth muscle and endothelial cells, and at a slightly higher level in the coronary vascular smooth muscle. |
| Post Translational Modifications | Ubiquitinated by NEDD4L in the presence of albumin.which promotes endocytosis and proteasomal degradation. |
| Function | Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable). |
| Protein Name | H(+/Cl(- Exchange Transporter 5Chloride Channel Protein 5Clc-5Chloride Transporter Clc-5 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Golgi Apparatus MembraneMulti-Pass Membrane ProteinEndosome MembraneCell Membrane |
| Alternative Antibody Names | Anti-H(+/Cl(- Exchange Transporter 5 antibodyAnti-Chloride Channel Protein 5 antibodyAnti-Clc-5 antibodyAnti-Chloride Transporter Clc-5 antibodyAnti-CLCN5 antibodyAnti-CLCK2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
