| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CLCN3 (Cytoplasmic Domain) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
CLCN3 |
| Gene ID: |
1182 |
| Uniprot ID: |
CLCN3_HUMAN |
| Immunogen Region: |
Cytoplasmic Domain |
| Specificity: |
Specific for CLCN3. |
| Immunogen: |
A synthetic peptide from the cytoplasmic domain of rat Chloride channel protein 3 (CLCN3) conjugated to an immunogenic carrier protein was used as the antigen. |
| Post Translational Modifications | N-glycosylated. |
| Function | Isoform 1: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. Isoform 2: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. |
| Protein Name | H(+/Cl(- Exchange Transporter 3Chloride Channel Protein 3Clc-3Chloride Transporter Clc-3 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Isoform 1: Early Endosome MembraneMulti-Pass Membrane ProteinLate Endosome MembraneLysosome MembraneCell MembraneIsoform 1 Is Localized Mainly In Late EndosomesIsoform 2: Golgi Apparatus MembraneCell ProjectionRuffle MembraneIsoform 2 Is Mainly Enriched In The GolgiColocalizes With Nherf1/Ebp50 In Membrane Ruffles |
| Alternative Antibody Names | Anti-H(+/Cl(- Exchange Transporter 3 antibodyAnti-Chloride Channel Protein 3 antibodyAnti-Clc-3 antibodyAnti-Chloride Transporter Clc-3 antibodyAnti-CLCN3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
