Anti-CLCA1 antibody (Internal) (STJ70721)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-CLCA1 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Experiments gave bands at approx 80kDa and 30kDa in Human Duodenum lysates. These bands correspond to earlier findings in literature with different antibodies (Gruber et al, Genomics. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | CLCA1 |
| Gene ID | 1179 |
| Uniprot ID | CLCA1_HUMAN |
| Accession Number | NP_001276.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | TVTSKTNKDTSK |
| Specificity | No cross-reactivity expected with CLCA2 and 3. |
Additional Info
| Post Translational Modifications | Glycosylated. The 125-kDa product is autoproteolytically processed by the metalloprotease domain and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37- to 41-kDa proteins. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity. |
| Function | May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. |
| Protein Name | Calcium-Activated Chloride Channel Regulator 1Calcium-Activated Chloride Channel Family Member 1Hclca1Calcium-Activated Chloride Channel Protein 1Cacc-1Hcacc-1 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | SecretedExtracellular SpaceCell MembranePeripheral Membrane ProteinExtracellular SideProtein That Remains Attached To The Plasma Membrane Appeared To Be Predominantly Localized To Microvilli |
| Alternative Antibody Names | Anti-Calcium-Activated Chloride Channel Regulator 1 antibodyAnti-Calcium-Activated Chloride Channel Family Member 1 antibodyAnti-Hclca1 antibodyAnti-Calcium-Activated Chloride Channel Protein 1 antibodyAnti-Cacc-1 antibodyAnti-Hcacc-1 antibodyAnti-CLCA1 antibodyAnti-CACC1 antibody |
Information sourced from Uniprot.org