Anti-Claudin 8 antibody (STJA0037886)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human Claudin 8
General Information
| Short Description | Rabbit monoclonal anti-Claudin 8 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | IHC 1:100-1:200 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | CLDN8 |
| Gene ID | 9073 |
| Uniprot ID | CLD8_HUMAN |
| Immunogen | A synthesized peptide derived from human Claudin 8 |
Additional Info
| Tissue Specificity | Expressed in the epididymis, mainly in the caput segment. |
| Post Translational Modifications | Ubiquitinated by the BCR(KLHL3) E3 ubiquitin ligase complex in the kidney, leading to its degradation. |
| Function | Can associate with other claudins to regulate tight junction structural and functional strand dynamics. May coassemble with CLDN4 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts. Cannot form tight junction strands on its own. |
| Protein Name | Claudin-8 |
| Database Links | Reactome: R-HSA-420029 |
| Cellular Localisation | Cell JunctionTight JunctionCell MembraneMulti-Pass Membrane ProteinLocalizes To Tight Junctions In All 3 Segments Of The EpididymisIn The Caput Found In The Lateral Margins Of Principal CellsAnd In The Corpus At The Interface Between Basal And Principal Cells |
| Alternative Antibody Names | Anti-Claudin-8 antibodyAnti-CLDN8 antibodyAnti-UNQ779 antibodyAnti-PRO1573 antibody |
Information sourced from Uniprot.org