Anti-Claudin 7 antibody [10E7-10B7-8G3] (STJA0033484)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
ImmunogenSynthesized peptide derived from human Claudin 7
General Information
| Short Description | Mouse monoclonal anti-Claudin 7 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 10E7-10B7-8G3 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Dilution Range | IHC 1:100-1:500 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | CLDN7 |
| Gene ID | 1366 |
| Uniprot ID | CLD7_HUMAN |
| Immunogen | Synthesized peptide derived from human Claudin 7 |
Additional Info
| Tissue Specificity | Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions. |
| Post Translational Modifications | Phosphorylated. |
| Function | Plays a major role in tight junction-specific obliteration of the intercellular space. |
| Protein Name | Claudin-7Cldn-7 |
| Database Links | Reactome: R-HSA-420029 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneCell JunctionTight JunctionCo-Localizes With Epcam At The Basolateral Cell Membrane And Tight Junction |
| Alternative Antibody Names | Anti-Claudin-7 antibodyAnti-Cldn-7 antibodyAnti-CLDN7 antibodyAnti-CEPTRL2 antibodyAnti-CPETRL2 antibody |
Information sourced from Uniprot.org