| Short Description : | Rabbit monoclonal Claudin 18.2 (1-100) antibody for use in IHC-P in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC-P |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | ZR451 |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | Affinity purified |
| Dilution Range: | 1:100-200 |
| Formulation: | Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin |
| Storage Instruction: | Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C. |
| Gene Symbol: | NRG3 |
| Gene ID: | 10718 |
| Uniprot ID: | NRG3_HUMAN |
| Immunogen: | Recombinant fragment (around aa1-100) of human Claudin18.2 protein |
| Immunogen Region: | 1-100 |
| Specificity: | Positive Control: Carcinomas |
| Tissue Specificity | Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. |
| Post Translational Modifications | Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. Extensive glycosylation precedes the proteolytic cleavage. Isoform 3 is glycosylated. |
| Function | Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. |
| Protein Name | Pro-Neuregulin-3 - Membrane-Bound IsoformPro-Nrg3 Cleaved Into - Neuregulin-3Nrg-3 |
| Database Links | Reactome: R-HSA-1227986Reactome: R-HSA-1236394Reactome: R-HSA-1250196Reactome: R-HSA-1250342Reactome: R-HSA-1250347Reactome: R-HSA-1251985Reactome: R-HSA-1257604Reactome: R-HSA-1963640Reactome: R-HSA-1963642Reactome: R-HSA-2219530Reactome: R-HSA-5673001Reactome: R-HSA-6785631Reactome: R-HSA-6811558Reactome: R-HSA-8847993Reactome: R-HSA-8863795Reactome: R-HSA-9664565Reactome: R-HSA-9665686 |
| Cellular Localisation | Pro-Neuregulin-3Membrane-Bound Isoform: Cell MembraneSingle-Pass Type I Membrane ProteinDoes Not Seem To Be ActiveNeuregulin-3: SecretedIsoform 3: Cell MembraneIsoform 3 Is Also Proteolytically Released As A Soluble Form |
| Alternative Antibody Names | Anti-Pro-Neuregulin-3 - Membrane-Bound Isoform antibodyAnti-Pro-Nrg3 Cleaved Into - Neuregulin-3 antibodyAnti-Nrg-3 antibodyAnti-NRG3 antibody |
Information sourced from Uniprot.org
