• Anti-Claudin 1 antibody (STJ16101323)

Anti-Claudin 1 antibody (STJ16101323)

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STJ16101323

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Host: Rabbit
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Claudin 1 is suitable for use in Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Formulation: Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Purification: Affinity purified
Dilution Range: IHC-P 1:25-1:100
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: CLDN1
Gene ID: 9076
Uniprot ID: CLD1_HUMAN
Tissue Specificity Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.
Function Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions. (Microbial infection) Acts as a co-receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell. Acts as a receptor for dengue virus.
Protein Name Claudin-1
Senescence-Associated Epithelial Membrane Protein
Database Links Reactome: R-HSA-420029
Cellular Localisation Cell Junction
Tight Junction
Cell Membrane
Multi-Pass Membrane Protein
Basolateral Cell Membrane
Associates With Cd81 And The Cldn1-Cd81 Complex Localizes To The Basolateral Cell Membrane
Alternative Antibody Names Anti-Claudin-1 antibody
Anti-Senescence-Associated Epithelial Membrane Protein antibody
Anti-CLDN1 antibody
Anti-CLD1 antibody
Anti-SEMP1 antibody
Anti-UNQ481 antibody
Anti-PRO944 antibody

Information sourced from Uniprot.org

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