| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Cytoskeleton-associated protein 5 (1446-1496 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CKAP5 |
| Gene ID: |
9793 |
| Uniprot ID: |
CKAP5_HUMAN |
| Immunogen Region: |
1446-1496 aa |
| Specificity: |
This antibody detects endogenous levels of CKAP5 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human CKAP5 at the amino acid range 1446-1496 |
| Function | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments. |
| Protein Name | Cytoskeleton-Associated Protein 5Colonic And Hepatic Tumor Overexpressed Gene ProteinCh-Tog |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-5663220Reactome: R-HSA-68877Reactome: R-HSA-8854518Reactome: R-HSA-9648025 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindle PoleSpindleChromosomeCentromereKinetochoreDetected On Centrosomes And Kinetochores During Interphase And Mitosis Independently From Tacc3 And ClathrinLocated To Spindle Poles And Microtubules During MitosisIn Complex With Tacc3 Localized To Microtubule Plus-Ends In Mitosis And InterphaseIn Complex With Tacc3 And Clathrin Localized To Inter-Microtubule Bridges In Mitotic SpindlesAccumulation Sites At Microtubule Plus Ends Protruded Approximately 100 Nm From Mapre1/Eb1 Sites In Interphase Cells |
| Alternative Antibody Names | Anti-Cytoskeleton-Associated Protein 5 antibodyAnti-Colonic And Hepatic Tumor Overexpressed Gene Protein antibodyAnti-Ch-Tog antibodyAnti-CKAP5 antibodyAnti-KIAA0097 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
