Anti-CITED2 antibody (1-100) (STJ11105425)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Cbp/P300-Interacting Transactivator 2 (1-100) antibody for use in WB and ELISA in rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CITED2 |
| Gene ID | 10370 |
| Uniprot ID | CITE2_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MADHMMAMNHGRFPDGTNGL HHHPAHRMGMGQFPSPHHHQ QQQPQHAFNALMGEHIHYGA GNMNATSGIRHAMGPGTVNG GHPPSALAPAARFNNSQFMG |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CITED2 (NP_001161860.1). |
Additional Info
| Function | Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Also acts as a transcriptional corepressor.interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis.potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP).stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region. |
| Protein Name | Cbp/P300-Interacting Transactivator 2Msg-Related Protein 1Mrg-1P35srj |
| Database Links | Reactome: R-HSA-1234158Reactome: R-HSA-8866906Reactome: R-HSA-8866907Reactome: R-HSA-9614657 |
| Cellular Localisation | NucleusColocalizes With Ep300 In Dot-Like Structures |
| Alternative Antibody Names | Anti-Cbp/P300-Interacting Transactivator 2 antibodyAnti-Msg-Related Protein 1 antibodyAnti-Mrg-1 antibodyAnti-P35srj antibodyAnti-CITED2 antibodyAnti-MRG1 antibody |
Information sourced from Uniprot.org