Anti-CITED1 antibody (116-166 aa) (STJ193966)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human CITE1 at the amino acid range 116-166
General Information
| Short Description | Rabbit polyclonal anti-Cbp/p300-interacting transactivator 1 (116-166 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CITED1 |
| Gene ID | 4435 |
| Uniprot ID | CITE1_HUMAN |
| Immunogen | Synthesized peptide derived from the human CITE1 at the amino acid range 116-166 |
| Immunogen Region | 116-166 aa |
| Specificity | This antibody detects endogenous levels of CITE1 at Human/Mouse |
Additional Info
| Post Translational Modifications | Phosphorylated. Phosphorylation changes in a cell cycle-dependent manner and reduces its transcriptional coactivator activity. |
| Function | Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling.stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner. |
| Protein Name | Cbp/P300-Interacting Transactivator 1Melanocyte-Specific Protein 1 |
| Database Links | Reactome: R-HSA-8866907Reactome: R-HSA-9018519 |
| Cellular Localisation | NucleusCytoplasmShuttles Between The Nucleus And The Cytoplasm By A Nuclear Export Signal And (Nes) In A Crm1-Dependent Manner |
| Alternative Antibody Names | Anti-Cbp/P300-Interacting Transactivator 1 antibodyAnti-Melanocyte-Specific Protein 1 antibodyAnti-CITED1 antibodyAnti-MSG1 antibody |
Information sourced from Uniprot.org