| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Cbp/p300-interacting transactivator 1 (116-166 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CITED1 |
| Gene ID: |
4435 |
| Uniprot ID: |
CITE1_HUMAN |
| Immunogen Region: |
116-166 aa |
| Specificity: |
This antibody detects endogenous levels of CITE1 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human CITE1 at the amino acid range 116-166 |
| Post Translational Modifications | Phosphorylated. Phosphorylation changes in a cell cycle-dependent manner and reduces its transcriptional coactivator activity. |
| Function | Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling.stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner. |
| Protein Name | Cbp/P300-Interacting Transactivator 1Melanocyte-Specific Protein 1 |
| Database Links | Reactome: R-HSA-8866907Reactome: R-HSA-9018519 |
| Cellular Localisation | NucleusCytoplasmShuttles Between The Nucleus And The Cytoplasm By A Nuclear Export Signal And (Nes) In A Crm1-Dependent Manner |
| Alternative Antibody Names | Anti-Cbp/P300-Interacting Transactivator 1 antibodyAnti-Melanocyte-Specific Protein 1 antibodyAnti-CITED1 antibodyAnti-MSG1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
