• Western blot analysis of lysates from mouse liver, using CIDEB Rabbit polyclonal antibody (STJ119321) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-CIDEB antibody (80-160) (STJ119321)

SKU:
STJ119321

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Host: Rabbit
Applications: WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CIDEB (80-160) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CIDEB
Gene ID: 27141
Uniprot ID: CIDEB_HUMAN
Immunogen Region: 80-160
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 80-160 of human CIDEB (NP_001305736).
Immunogen Sequence: DGTAVDSEDFFQLLEDDTCL MVLQSGQSWSPTRSGVLSYG LGRERPKHSKDIARFTFDVY KQNPRDLFGSLNVKATFYGL Y
Tissue Specificity Highly expressed in liver and small intestine and, at lower levels, in colon, kidney and spleen.
Function Lipid transferase specifically expressed in hepatocytes, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion. Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage. Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Promotes lipid exchange and lipid droplet fusion in both small and large lipid droplet-containing hepatocytes. In addition to its role in lipid droplet fusion, also involved in cytoplasmic vesicle biogenesis and transport. Required for very-low-density lipoprotein (VLDL) lipidation and maturation. Probably involved in the biogenesis of VLDL transport vesicles by forming a COPII vesicle coat and facilitating the formation of endoplasmic reticulum-derived large vesicles. Also involved in sterol-regulated export of the SCAP-SREBP complex, composed of SCAP, SREBF1/SREBP1 and SREBF2/SREBP2, by promoting loading of SCAP-SREBP into COPII vesicles. May also activate apoptosis. (Microbial infection) Involved in Hepatatis C virus (HCV) assembly and required for HCV entry into hepatocytes.
Protein Name Lipid Transferase Cideb
Cell Death Activator Cide-B
Cell Death-Inducing Dffa-Like Effector B
Cellular Localisation Lipid Droplet
Endoplasmic Reticulum Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Golgi Apparatus
Cytoplasmic Vesicle
Copi-Coated Vesicle
Enriched At Lipid Droplet Contact Sites
Alternative Antibody Names Anti-Lipid Transferase Cideb antibody
Anti-Cell Death Activator Cide-B antibody
Anti-Cell Death-Inducing Dffa-Like Effector B antibody
Anti-CIDEB antibody

Information sourced from Uniprot.org

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