Anti-CIB2 antibody (21-70 aa) (STJ92290)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CIB2 at the amino acid range 21-70
General Information
| Short Description | Rabbit polyclonal anti-Calcium and integrin-binding family member 2 (21-70 aa) for use in IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CIB2 |
| Gene ID | 10518 |
| Uniprot ID | CIB2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CIB2 at the amino acid range 21-70 |
| Immunogen Region | 21-70 aa |
| Specificity | CIB2 Polyclonal Antibody detects endogenous levels of CIB2 protein. |
Additional Info
| Function | Calcium- and integrin-binding protein that plays a role in intracellular calcium homeostasis. Acts as an auxiliary subunit of the sensory mechanoelectrical transduction (MET) channel in hair cells. Essential for mechanoelectrical transduction (MET) currents in auditory hair cells and thereby required for hearing. Regulates the function of hair cell mechanotransduction by controlling the distribution of transmembrane channel-like proteins TMC1 and TMC2, and by regulating the function of the MET channels in hair cells. Required for the maintenance of auditory hair cell stereocilia bundle morphology and function and for hair-cell survival in the cochlea. Critical for proper photoreceptor cell maintenance and function. Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release. |
| Protein Name | Calcium And Integrin-Binding Family Member 2Kinase-Interacting Protein 2Kip 2 |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | CytoplasmCell ProjectionStereociliumPhotoreceptor Inner SegmentCiliumPhotoreceptor Outer SegmentCell MembraneSarcolemmaColocalizes With Itga7 At The Myotendinous Junctions (Mtj) And At The Neuromuscular Junctions (Nmj)Located Mainly In Stereocilia And At The Apical Surface Of Hair Cells Of The CochleaLocalizes In The Cuticular Plate Along And At The Tip Of The Stereocilia Of Vestibular Sensory Hair Cells |
| Alternative Antibody Names | Anti-Calcium And Integrin-Binding Family Member 2 antibodyAnti-Kinase-Interacting Protein 2 antibodyAnti-Kip 2 antibodyAnti-CIB2 antibodyAnti-KIP2 antibody |
Information sourced from Uniprot.org