| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CIAO1 |
| Gene ID: | 9391 |
| Uniprot ID: | CIAO1_HUMAN |
| Immunogen Region: | 1-339 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-339 of human CIAO1 (NP_004795.1). |
| Immunogen Sequence: | MKDSLVLLGRVPAHPDSRCW FLAWNPAGTLLASCGGDRRI RIWGTEGDSWICKSVLSEGH QRTVRKVAWSPCGNYLASAS FDATTCIWKKNQDDFECVTT LEGHENEVKSVAWAPSGNLL ATCSRDKSVWVWEVDEEDEY ECVSVLNSHTQDVKHVVWHP SQELLASASYDDTVKLYREE EDDWVCCATLEGHESTVWSL AFDPSGQRLASCSDDRTVRI WRQYLPGNEQGVACSGSDP |
| Function | Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. |
| Protein Name | Probable Cytosolic Iron-Sulfur Protein Assembly Protein Ciao1Wd Repeat-Containing Protein 39 |
| Database Links | Reactome: R-HSA-2564830 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Probable Cytosolic Iron-Sulfur Protein Assembly Protein Ciao1 antibodyAnti-Wd Repeat-Containing Protein 39 antibodyAnti-CIAO1 antibodyAnti-CIA1 antibodyAnti-WDR39 antibody |
Information sourced from Uniprot.org