| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Cooperates with B4GALT4 galactosyltransferase and B3GNT7 N-acetylglucosaminyltransferase to construct and elongate the sulfated disaccharide unit ->3Galbeta1->4(6-sulfoGlcNAcbeta)1-> within keratan sulfate polymer. Involved in biosynthesis of keratan sulfate in cornea, with an impact on proteoglycan fibril organization and corneal transparency. Involved in sulfation of endothelial mucins such as GLYCAM1. |
| Protein Name | Carbohydrate Sulfotransferase 6Corneal N-Acetylglucosamine-6-O-SulfotransferaseC-Glcnac6stHcgn6stGalactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 4-BetaGst4-BetaN-Acetylglucosamine 6-O-Sulfotransferase 5Glcnac6st-5Gn6st-5 |
| Database Links | Reactome: R-HSA-2022854Reactome: R-HSA-3656225 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Carbohydrate Sulfotransferase 6 antibodyAnti-Corneal N-Acetylglucosamine-6-O-Sulfotransferase antibodyAnti-C-Glcnac6st antibodyAnti-Hcgn6st antibodyAnti-Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 4-Beta antibodyAnti-Gst4-Beta antibodyAnti-N-Acetylglucosamine 6-O-Sulfotransferase 5 antibodyAnti-Glcnac6st-5 antibodyAnti-Gn6st-5 antibodyAnti-CHST6 antibody |
Information sourced from Uniprot.org
