| Function | Sulfotransferase involved in SELL/L-selectin ligand biosynthesis pathway. Catalyzes the transfer of the sulfate group from 3'-phospho-5'-adenylyl sulfate (PAPS) onto the hydroxyl group at C-6 position of the non-reducing N-acetylglucosamine (GlcNAc) residue within O-linked mucin-type glycans. Contributes to generate sialyl 6-sulfo Lewis X determinant (also known as MECA-79 epitope) for SELL recognition, a prerequisite for continuous lymphocyte homing into peripheral lymph nodes and antigen immune surveillance. Transfers the sulfate group primarily on core 2 GlcNAcbeta1-6(Galbeta1-3)GalNAcalphaSer/Thr and extended core 1 GlcNAcbeta1-3Galbeta1-3GalNAcalphaSer/Thr based O-linked glycans on CD34 and GLYCAM1 peripheral node addressins (PNAds) expressed on the lumenal side of high endothelial venules (HEVs). The recognition of PNAds by SELL initiates a multistep process comprising tethering and rolling of blood lymphocytes on HEVs against the blood flow, followed by chemokine signaling, integrin-mediated lymphocyte adhesion onto endothelial cells and lymphocyte transendothelial migration. Modulates rolling velocity and differential T and B lymphocyte recruitment into peripheral lymph nodes, with a major role in B lymphocyte homing. Might be redundant in sulfation of MADCAM1 and lymphocyte trafficking to mesenteric lymph nodes. Can also sulfonate core 3 GlcNAcbeta1-3GalNAc-R based glycans as well as GlcNAcbeta1-3Galbeta1-Glc, GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharides, which might be ectopically expressed during tumorigenesis. |
| Protein Name | Carbohydrate Sulfotransferase 4Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 3Gst-3High Endothelial Cells N-Acetylglucosamine 6-O-SulfotransferaseHec-Glcnac6stL-Selectin Ligand SulfotransferaseLsstN-Acetylglucosamine 6-O-Sulfotransferase 2Glcnac6st-2Gn6st-2 |
| Database Links | Reactome: R-HSA-913709 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Carbohydrate Sulfotransferase 4 antibodyAnti-Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 3 antibodyAnti-Gst-3 antibodyAnti-High Endothelial Cells N-Acetylglucosamine 6-O-Sulfotransferase antibodyAnti-Hec-Glcnac6st antibodyAnti-L-Selectin Ligand Sulfotransferase antibodyAnti-Lsst antibodyAnti-N-Acetylglucosamine 6-O-Sulfotransferase 2 antibodyAnti-Glcnac6st-2 antibodyAnti-Gn6st-2 antibodyAnti-CHST4 antibody |
Information sourced from Uniprot.org
