| Short Description : | Rabbit polyclonal CHRM3 (390-590) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CHRM3 |
| Gene ID: | 1131 |
| Uniprot ID: | ACM3_HUMAN |
| Immunogen Region: | 390-590 |
| Immunogen Sequence: | QVPEEELGMVDLERKADKLQ AQKSVDDGGSFPKSFSKLPI QLESAVDTAKTSDVNSSVGK STATLPLSFKEATLAKRFAL KTRSQI |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 390-475 of human CHRM3 (NP_000731.1). |
| Function | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. |
| Protein Name | Muscarinic Acetylcholine Receptor M3 |
| Database Links | Reactome: R-HSA-390648Reactome: R-HSA-399997Reactome: R-HSA-416476 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembraneBasolateral Cell MembraneEndoplasmic Reticulum MembraneColocalizes With Tmem147 In The Endoplasmic Reticulum (Er) MembraneTmem147 Impairs Its Trafficking To The Cell Membrane Leading To Its Retention In The Er Membrane |
| Alternative Antibody Names | Anti-Muscarinic Acetylcholine Receptor M3 antibodyAnti-CHRM3 antibody |
Information sourced from Uniprot.org
