| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Calcineurin B homologous protein 2 (101-150 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:40000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CHP2 |
| Gene ID: |
63928 |
| Uniprot ID: |
CHP2_HUMAN |
| Immunogen Region: |
101-150 aa |
| Specificity: |
CHP2 Polyclonal Antibody detects endogenous levels of CHP2 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human CHP2 at the amino acid range 101-150 |
| Function | Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus. |
| Protein Name | Calcineurin B Homologous Protein 2Hepatocellular Carcinoma-Associated Antigen 520 |
| Cellular Localisation | NucleusCytoplasmCell MembranePredominantly Localized In A Juxtanuclear RegionColocalizes With Slc9a3 In The Juxtanuclear Region And At The Plasma MembraneExported From The Nucleus To The Cytoplasm Through A Nuclear Export Signal (Nes) PathwayMay Shuttle Between Nucleus And Cytoplasm |
| Alternative Antibody Names | Anti-Calcineurin B Homologous Protein 2 antibodyAnti-Hepatocellular Carcinoma-Associated Antigen 520 antibodyAnti-CHP2 antibodyAnti-HCA520 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
