Anti-CHP2 antibody (101-150 aa) (STJ92280)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CHP2 at the amino acid range 101-150
General Information
| Short Description | Rabbit polyclonal anti-Calcineurin B homologous protein 2 (101-150 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CHP2 |
| Gene ID | 63928 |
| Uniprot ID | CHP2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CHP2 at the amino acid range 101-150 |
| Immunogen Region | 101-150 aa |
| Specificity | CHP2 Polyclonal Antibody detects endogenous levels of CHP2 protein. |
Additional Info
| Function | Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus. |
| Protein Name | Calcineurin B Homologous Protein 2Hepatocellular Carcinoma-Associated Antigen 520 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmCell MembranePredominantly Localized In A Juxtanuclear RegionColocalizes With Slc9a3 In The Juxtanuclear Region And At The Plasma MembraneExported From The Nucleus To The Cytoplasm Through A Nuclear Export Signal (Nes) PathwayMay Shuttle Between Nucleus And Cytoplasm |
| Alternative Antibody Names | Anti-Calcineurin B Homologous Protein 2 antibodyAnti-Hepatocellular Carcinoma-Associated Antigen 520 antibodyAnti-CHP2 antibodyAnti-HCA520 antibody |
Information sourced from Uniprot.org