Anti-CHM antibody [R36-7A-8] (STJA0035569)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human CHM
General Information
| Short Description | Rabbit monoclonal anti-CHM for use in WB, ICC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R36-7A-8 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200 |
| Formulation | Liquid in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | CHM |
| Gene ID | 1121 |
| Uniprot ID | RAE1_HUMAN |
| Immunogen | A synthesized peptide derived from human CHM |
Additional Info
| Function | Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins.this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation. |
| Protein Name | Rab Proteins Geranylgeranyltransferase Component A 1Choroideremia ProteinRab Escort Protein 1Rep-1Tcd Protein |
| Database Links | Reactome: R-HSA-6803205Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Rab Proteins Geranylgeranyltransferase Component A 1 antibodyAnti-Choroideremia Protein antibodyAnti-Rab Escort Protein 1 antibodyAnti-Rep-1 antibodyAnti-Tcd Protein antibodyAnti-CHM antibodyAnti-REP1 antibodyAnti-TCD antibody |
Information sourced from Uniprot.org