| Short Description : | Rabbit polyclonal anti-Acidic mammalian chitinase for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CHIA |
| Gene ID: | 27159 |
| Uniprot ID: | CHIA_HUMAN |
| Immunogen: | Synthesized peptide derived from human CHIA |
| Specificity: | This antibody detects endogenous levels of CHIA at Human, Mouse, Rat |
| Function | Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. |
| Protein Name | Acidic Mammalian ChitinaseAmcaseLung-Specific Protein Tsa1902 |
| Database Links | Reactome: R-HSA-189085 |
| Cellular Localisation | Isoform 1: SecretedSecretion Depends On Egfr ActivityIsoform 2: CytoplasmIsoform 3: Cytoplasm |
| Alternative Antibody Names | Anti-Acidic Mammalian Chitinase antibodyAnti-Amcase antibodyAnti-Lung-Specific Protein Tsa1902 antibodyAnti-CHIA antibody |
Information sourced from Uniprot.org
