Anti-CHD6 antibody (STJ190697)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Chromodomain-helicase-DNA-binding protein 6 for use in IHC and IF in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-300IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CHD6 |
| Gene ID | 84181 |
| Uniprot ID | CHD6_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | CHD6 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | ATP-dependent chromatin-remodeling factor. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin.nucleosome disruption requires ATP. Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. |
| Protein Name | Chromodomain-Helicase-Dna-Binding Protein 6Chd-6Atp-Dependent Helicase Chd6Radiation-Induced Gene B Protein |
| Database Links | |
| Cellular Localisation | NucleusNucleoplasmEnriched At Sites Of Mrna SynthesisDuring Influenza A Virus InfectionLocalizes To Inactive Chromatin |
| Alternative Antibody Names | Anti-Chromodomain-Helicase-Dna-Binding Protein 6 antibodyAnti-Chd-6 antibodyAnti-Atp-Dependent Helicase Chd6 antibodyAnti-Radiation-Induced Gene B Protein antibodyAnti-CHD6 antibodyAnti-CHD5 antibodyAnti-KIAA1335 antibodyAnti-RIGB antibody |
Information sourced from Uniprot.org