| Tissue Specificity | Frequently overexpressed in hepatomacellular carcinomas. |
| Function | ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage. Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage. Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair. Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner. Chromatin remodeling activity promotes PARP2 removal from chromatin. |
| Protein Name | Chromodomain-Helicase-Dna-Binding Protein 1-LikeAmplified In Liver Cancer Protein 1 |
| Database Links | Reactome: R-HSA-5696395Reactome: R-HSA-5696400 |
| Cellular Localisation | NucleusChromosomeLocalizes At Sites Of Dna DamageRecruited By Histones H2b And H3 Poly-Adp-Ribosylated On 'Ser-6' And 'Ser-10'Respectively (H2bs6adpr And H3s10adpr) By Parp1 Or Parp2 |
| Alternative Antibody Names | Anti-Chromodomain-Helicase-Dna-Binding Protein 1-Like antibodyAnti-Amplified In Liver Cancer Protein 1 antibodyAnti-CHD1L antibodyAnti-ALC1 antibody |
Information sourced from Uniprot.org
