Anti-CHCHD3 antibody [30000000000] (STJA0032687)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPurified recombinant human CHCHD3 protein fragments expressed in E.coli.
General Information
| Short Description | Mouse monoclonal anti-CHCHD3 for use in WB and IHC-P in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 30000000000 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100 |
| Formulation | Liquid in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | CHCHD3 |
| Gene ID | 54927 |
| Uniprot ID | MIC19_HUMAN |
| Immunogen | Purified recombinant human CHCHD3 protein fragments expressed in E.coli. |
Additional Info
| Tissue Specificity | Detected at low levels in brain, placenta, lung, liver, kidney and pancreas with increased levels in heart and skeletal muscle. Higher expression in primary lung cancers than in normal lung tissue. |
| Function | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. |
| Protein Name | Micos Complex Subunit Mic19Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 3 |
| Database Links | Reactome: R-HSA-1268020Reactome: R-HSA-8949613 |
| Cellular Localisation | Mitochondrion Inner MembraneLipid-AnchorIntermembrane SideCytoplasmNucleusMitochondrion |
| Alternative Antibody Names | Anti-Micos Complex Subunit Mic19 antibodyAnti-Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 3 antibodyAnti-CHCHD3 antibodyAnti-MIC19 antibodyAnti-MINOS3 antibody |
Information sourced from Uniprot.org