Anti-CGRP antibody (350-410) {Biotin} (STJ506113)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationBiotin
IsotypeIgG
ImmunogenSynthetic peptide corresponding to amino acids within region 350-410 mouse Calcitonin gene-related peptide 1.
General Information
| Short Description | Rabbit polyclonal antibody anti-CGRP (350-410) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IP/WB |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Biotin |
| Concentration | 0.5-1.5 µg/µl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500-1:5, 000ELISA: 1:50, 000IP: 1:200 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Calca |
| Gene ID | 12310 |
| Uniprot ID | CALCA_MOUSE |
| Immunogen | Synthetic peptide corresponding to amino acids within region 350-410 mouse Calcitonin gene-related peptide 1. |
| Immunogen Region | 350-410 |
Additional Info
| Tissue Specificity | Detected in nerve cells of cerebrum, hippocampus and pons/midbrain in newborns, and only in nerve cells of pons/midbrain in adult. |
| Function | CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex. Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex. |
| Protein Name | Calcitonin Gene-Related Peptide 1Cgrp1Alpha-Type CgrpCalcitonin Gene-Related Peptide ICgrp-I |
| Database Links | Reactome: R-MMU-418555Reactome: -MMU-419812 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Calcitonin Gene-Related Peptide 1 antibodyAnti-Cgrp1 antibodyAnti-Alpha-Type Cgrp antibodyAnti-Calcitonin Gene-Related Peptide I antibodyAnti-Cgrp-I antibodyAnti-Calca antibodyAnti-Calc antibody |
Information sourced from Uniprot.org