| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Cofilin-2 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CFL2 |
| Gene ID: | 1073 |
| Uniprot ID: | COF2_HUMAN |
| Specificity: | This antibody detects endogenous levels of Cofilin 2 at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human Cofilin 2 |
| Post Translational Modifications | The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal. |
| Function | Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere. |
| Protein Name | Cofilin-2Cofilin - Muscle Isoform |
| Cellular Localisation | Nucleus MatrixCytoplasmCytoskeletonColocalizes With Cspr3 In The Z Line Of Sarcomeres |
| Alternative Antibody Names | Anti-Cofilin-2 antibodyAnti-Cofilin - Muscle Isoform antibodyAnti-CFL2 antibody |
Information sourced from Uniprot.org