Anti-CFI antibody (441-490 aa) (STJ93017)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CFI at the amino acid range 441-490
General Information
| Short Description | Rabbit polyclonal anti-Complement factor I (441-490 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CFI |
| Gene ID | 3426 |
| Uniprot ID | CFAI_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CFI at the amino acid range 441-490 |
| Immunogen Region | 441-490 aa |
| Specificity | Factor I Polyclonal Antibody detects endogenous levels of Factor I protein. |
Additional Info
| Function | Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization. |
| Protein Name | Complement Factor IC3b/C4b Inactivator Cleaved Into - Complement Factor I Heavy Chain - Complement Factor I Light Chain |
| Database Links | Reactome: R-HSA-977606 |
| Cellular Localisation | SecretedExtracellular Space |
| Alternative Antibody Names | Anti-Complement Factor I antibodyAnti-C3b/C4b Inactivator Cleaved Into - Complement Factor I Heavy Chain - Complement Factor I Light Chain antibodyAnti-CFI antibodyAnti-IF antibody |
Information sourced from Uniprot.org