• Western blot analysis of extracts of various cell lines, using CFD antibody (STJ11104181) at1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-CFD antibody (26-253) [S4181RM] (STJ11104181)

SKU:
STJ11104181

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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-Complement Factor D (26-253) is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Clone ID: S4181RM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CFD
Gene ID: 1675
Uniprot ID: CFAD_HUMAN
Immunogen Region: 26-253
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 26-253 of human CFD (P00746).
Immunogen Sequence: ILGGREAEAHARPYMASVQL NGAHLCGGVLVAEQWVLSAA HCLEDAADGKVQVLLGAHSL SQPEPSKRLYDVLRAVPHPD SQPDTIDHDLLLLQLSEKAT LGPAVRPLPWQRVDRDVAPG TLCDVAGWGIVNHAGRRPDS LQHVLLPVLDRATCNRRTHH DGAITERLMCAESNRRDSCK GDSGGPLVCGGVLEGVVTSG SRVCGNRKKPGIYTRVASYA AWIDSVLA
Function Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
Protein Name Complement Factor D
Adipsin
C3 Convertase Activator
Properdin Factor D
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-173736
Reactome: R-HSA-6798695
Cellular Localisation Secreted
Alternative Antibody Names Anti-Complement Factor D antibody
Anti-Adipsin antibody
Anti-C3 Convertase Activator antibody
Anti-Properdin Factor D antibody
Anti-CFD antibody
Anti-DF antibody
Anti-PFD antibody

Information sourced from Uniprot.org

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