Anti-CES2 antibody (310-410) (STJ23101)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CES2 (310-410) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CES2 |
| Gene ID | 8824 |
| Uniprot ID | EST2_HUMAN |
| Immunogen Region | 310-410 |
| Immunogen Sequence | IPGVVDGVFLPRHPQELLAS ADFQPVPSIVGVNNNEFGWL IPKVMRIYDTQKEMDREASQ AALQKMLTLLMLPPTFGDLL REEYIGDNGDPQTLQAQFQE M |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 310-410 of human CES2 (NP_003860.3). |
Additional Info
| Tissue Specificity | Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum. |
| Post Translational Modifications | Glycosylated. |
| Function | Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine. Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol. Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins. |
| Protein Name | Cocaine EsteraseCarboxylesterase 2Ce-2Hce-2Methylumbelliferyl-Acetate Deacetylase 2 |
| Database Links | Reactome: R-HSA-211945Reactome: R-HSA-9749641 |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Antibody Names | Anti-Cocaine Esterase antibodyAnti-Carboxylesterase 2 antibodyAnti-Ce-2 antibodyAnti-Hce-2 antibodyAnti-Methylumbelliferyl-Acetate Deacetylase 2 antibodyAnti-CES2 antibodyAnti-ICE antibody |
Information sourced from Uniprot.org