| Short Description : | Rabbit polyclonal CES2 (310-410) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CES2 |
| Gene ID: | 8824 |
| Uniprot ID: | EST2_HUMAN |
| Immunogen Region: | 310-410 |
| Immunogen Sequence: | IPGVVDGVFLPRHPQELLAS ADFQPVPSIVGVNNNEFGWL IPKVMRIYDTQKEMDREASQ AALQKMLTLLMLPPTFGDLL REEYIGDNGDPQTLQAQFQE M |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 310-410 of human CES2 (NP_003860.3). |
| Tissue Specificity | Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum. |
| Post Translational Modifications | Glycosylated. |
| Function | Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine. Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol. Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins. |
| Protein Name | Cocaine EsteraseCarboxylesterase 2Ce-2Hce-2Methylumbelliferyl-Acetate Deacetylase 2 |
| Database Links | Reactome: R-HSA-211945Reactome: R-HSA-9749641 |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Antibody Names | Anti-Cocaine Esterase antibodyAnti-Carboxylesterase 2 antibodyAnti-Ce-2 antibodyAnti-Hce-2 antibodyAnti-Methylumbelliferyl-Acetate Deacetylase 2 antibodyAnti-CES2 antibodyAnti-ICE antibody |
Information sourced from Uniprot.org
![Anti-Papillomavirus type 1 E2-protein antibody (310-410 aa) [3E8] (STJA0002813)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/150079/299788/STJA0002813_1__63342.1633363892.png?c=1 "Anti-Papillomavirus type 1 E2-protein antibody (310-410 aa) [3E8] (STJA0002813)")
