Immunofluorescence analysis of MCF-7 cells using CES2 antibody (STJ23101). Blue: DAPI for nuclear staining.

Anti-CES2 antibody (310-410) (STJ23101)

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STJ23101
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: WB/IF/ICC/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CES2
Gene ID: 8824
Uniprot ID: EST2_HUMAN
Immunogen Region: 310-410
Specificity: A synthetic peptide corresponding to a sequence within amino acids 310-410 of human CES2 (NP_003860.3).
Immunogen Sequence: IPGVVDGVFLPRHPQELLAS ADFQPVPSIVGVNNNEFGWL IPKVMRIYDTQKEMDREASQ AALQKMLTLLMLPPTFGDLL REEYIGDNGDPQTLQAQFQE M
Tissue Specificity Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.
Post Translational Modifications Glycosylated.
Function Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine. Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol. Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins.
Protein Name Cocaine Esterase
Carboxylesterase 2
Ce-2
Hce-2
Methylumbelliferyl-Acetate Deacetylase 2
Database Links Reactome: R-HSA-211945
Reactome: R-HSA-9749641
Cellular Localisation Endoplasmic Reticulum Lumen
Alternative Antibody Names Anti-Cocaine Esterase antibody
Anti-Carboxylesterase 2 antibody
Anti-Ce-2 antibody
Anti-Hce-2 antibody
Anti-Methylumbelliferyl-Acetate Deacetylase 2 antibody
Anti-CES2 antibody
Anti-ICE antibody

Information sourced from Uniprot.org

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