Anti-Ceruloplasmin antibody [R18-3Y-7] (STJA0035646)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human Ceruloplasmin
General Information
| Short Description | Rabbit monoclonal anti-Ceruloplasmin for use in WB in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R18-3Y-7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | Liquid in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | CP |
| Gene ID | 1356 |
| Uniprot ID | CERU_HUMAN |
| Immunogen | A synthesized peptide derived from human Ceruloplasmin |
Additional Info
| Tissue Specificity | Expressed by the liver and secreted in plasma. |
| Function | Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols. Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis. |
| Protein Name | CeruloplasminCuproxidase CeruloplasminFerroxidase CeruloplasminGlutathione Peroxidase CeruloplasminGlutathione-Dependent Peroxiredoxin Ceruloplasmin |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-425410Reactome: R-HSA-5619049Reactome: R-HSA-5619060Reactome: R-HSA-8957275Reactome: R-HSA-917937 |
| Cellular Localisation | SecretedColocalizes With Gcp1 In Secretory Intracellular Compartments |
| Alternative Antibody Names | Anti-Ceruloplasmin antibodyAnti-Cuproxidase Ceruloplasmin antibodyAnti-Ferroxidase Ceruloplasmin antibodyAnti-Glutathione Peroxidase Ceruloplasmin antibodyAnti-Glutathione-Dependent Peroxiredoxin Ceruloplasmin antibodyAnti-CP antibody |
Information sourced from Uniprot.org