Anti-Ceruloplasmin antibody (366-572) [S2MR] (STJ11103232)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Ceruloplasmin (366-572) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S2MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:5000-1:30000IHC-P:1:5000-1:20000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CP |
| Gene ID | 1356 |
| Uniprot ID | CERU_HUMAN |
| Immunogen Region | 366-572 |
| Immunogen Sequence | IRGKHVRHYYIAAEEIIWNY APSGIDIFTKENLTAPGSDS AVFFEQGTTRIGGSYKKLVY REYTDASFTNRKERGPEEEH LGILGPVIWAEVGDTIRVTF HNKGAYPLSIEPIGVRFNKN NEGTYYSPNYNPQSRSVPPS ASHVAPTETFTYEWTVPKEV GPTNADPVCLAKMYYSAVDP TKDIFTGLIGPMKICKKGSL HANGRQK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 366-572 of human Ceruloplasmin (NP_000087.1). |
Additional Info
| Tissue Specificity | Expressed by the liver and secreted in plasma. |
| Function | Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols. Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis. |
| Protein Name | CeruloplasminCuproxidase CeruloplasminFerroxidase CeruloplasminGlutathione Peroxidase CeruloplasminGlutathione-Dependent Peroxiredoxin Ceruloplasmin |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-425410Reactome: R-HSA-5619049Reactome: R-HSA-5619060Reactome: R-HSA-8957275Reactome: R-HSA-917937 |
| Cellular Localisation | SecretedColocalizes With Gcp1 In Secretory Intracellular Compartments |
| Alternative Antibody Names | Anti-Ceruloplasmin antibodyAnti-Cuproxidase Ceruloplasmin antibodyAnti-Ferroxidase Ceruloplasmin antibodyAnti-Glutathione Peroxidase Ceruloplasmin antibodyAnti-Glutathione-Dependent Peroxiredoxin Ceruloplasmin antibodyAnti-CP antibody |
Information sourced from Uniprot.org