Anti-CERS6 antibody (73-123 aa) (STJ197999)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human CERS6 at the amino acid range 73-123
General Information
| Short Description | Rabbit polyclonal anti-Ceramide synthase 6 (73-123 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CERS6 |
| Gene ID | 253782 |
| Uniprot ID | CERS6_HUMAN |
| Immunogen | Synthesized peptide derived from the human CERS6 at the amino acid range 73-123 |
| Immunogen Region | 73-123 aa |
| Specificity | This antibody detects endogenous levels of human CERS6 |
Additional Info
| Function | Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA.C16:0-CoA). Can use other acyl donors, but with less efficiency. N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Ceramides generated by CERS6 play a role in inflammatory response. Acts as a regulator of metabolism and hepatic lipid accumulation. Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity. |
| Protein Name | Ceramide Synthase 6Cers6Lag1 Longevity Assurance Homolog 6Sphingoid Base N-Palmitoyltransferase Cers6 |
| Database Links | Reactome: R-HSA-1660661 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Ceramide Synthase 6 antibodyAnti-Cers6 antibodyAnti-Lag1 Longevity Assurance Homolog 6 antibodyAnti-Sphingoid Base N-Palmitoyltransferase Cers6 antibodyAnti-CERS6 antibodyAnti-LASS6 antibody |
Information sourced from Uniprot.org