Anti-CERS2 antibody [3D9] (STJA0032649)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
ImmunogenPurified recombinant human CERS2 protein fragments expressed in E.coli.
General Information
| Short Description | Mouse monoclonal anti-CERS2 for use in WB and IHC-P in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 3D9 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100 |
| Formulation | Liquid in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | CERS2 |
| Gene ID | 29956 |
| Uniprot ID | CERS2_HUMAN |
| Immunogen | Purified recombinant human CERS2 protein fragments expressed in E.coli. |
Additional Info
| Tissue Specificity | Expressed in kidney, liver, brain, heart, placenta and lung. |
| Post Translational Modifications | Acetylated. Deacetylation by SIRT3 increases enzyme activity and promotes mitochondrial ceramide accumulation. Phosphorylated at the C-terminus by CK2, leading to increase the ceramide synthase activity. |
| Function | Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very-long-chain fatty acyl-CoA (chain length C22-C27). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Plays a non-redundant role in the synthesis of ceramides with very-long-chain fatty acids in kidney, liver and brain. Regulates the abundance of myelin-specific sphingolipids galactosylceramide and sulfatide that affects myelin sheath architecture and motor neuron functions. |
| Protein Name | Ceramide Synthase 2Cers2Lag1 Longevity Assurance Homolog 2Sp260Sphingosine N-Acyltransferase Cers2Tumor Metastasis-Suppressor Gene 1 ProteinVery-Long-Chain Ceramide Synthase Cers2 |
| Database Links | Reactome: R-HSA-1660661 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Ceramide Synthase 2 antibodyAnti-Cers2 antibodyAnti-Lag1 Longevity Assurance Homolog 2 antibodyAnti-Sp260 antibodyAnti-Sphingosine N-Acyltransferase Cers2 antibodyAnti-Tumor Metastasis-Suppressor Gene 1 Protein antibodyAnti-Very-Long-Chain Ceramide Synthase Cers2 antibodyAnti-CERS2 antibodyAnti-LASS2 antibodyAnti-TMSG1 antibody |
Information sourced from Uniprot.org