| Post Translational Modifications | Phosphorylation by PLK1 is required for binding to BTRC in prometaphase. Phosphorylated directly or indirectly by NEK2. NEK2-mediated phosphorylation promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis. Ubiquitinated and targeted for proteasomal degradation in early mitosis by the SCF(BTRC) and/or SCF(FBXW11) E3 ubiquitin-protein ligase complexes. Degradation is complete by prometaphase and is required for removal of CDK5RAP2 from the peripheral pericentriolar material and subsequent centriole separation. |
| Function | Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase. Contributes to CROCC/rootletin filament formation. |
| Protein Name | Centrosomal Protein Of 68 KdaCep68 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeLocalizes To Thin Fibers Protruding Away From The Proximal Ends Of The Two CentriolesDissociates From Interphase Centrosomes At The Onset Of Mitosis |
| Alternative Antibody Names | Anti-Centrosomal Protein Of 68 Kda antibodyAnti-Cep68 antibodyAnti-CEP68 antibodyAnti-KIAA0582 antibody |
Information sourced from Uniprot.org
