Anti-CEP164 nanobody [36Z] (STJN000702)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-His
General Information
| Short Description | Alpaca monoclonal nanobody anti-CEP164 is suitable for use in ELISA research applications. |
| Applications | ELISA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 36Z |
| Isotype | VHH-His |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Purified by Nickel column. |
| Dilution Range | ELISA: 1:2000-1:20000 |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact with the lab for this information. |
Target Information
| Gene Symbol | CEP164 |
| Gene ID | 22897 |
| Uniprot ID | CE164_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-186 is induced upon DNA-damage caused by treatment with IR irradiation, UV irradiation, hydroxyurea or amphidicolin. Also MDC1-mediated chromatin remodeling is critical for DNA damage-induced phosphorylation. |
| Function | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. |
| Protein Name | Centrosomal Protein Of 164 KdaCep164 |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleNucleusLocalizes Specifically To Very Distally Located Appendage Structures On The Mature Centriole From Which Initiate Pc FormationPersisted At Centrioles Throughout MitosisExpressed In Chromatin-Enriched Nuclear Fraction Of Hela CellsIn Response To Dna DamageIt Translocates To Nuclear Foci That Contain The Dna Damage Response Proteins Kat5/Tip60 And Chek1 |
| Alternative Nanobody Names | Anti-Centrosomal Protein Of 164 Kda nanobodyAnti-Cep164 nanobodyAnti-CEP164 nanobodyAnti-KIAA1052 nanobodyAnti-NPHP15 nanobody |
Information sourced from Uniprot.org