• Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using AZI1 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of lysates from HUVEC cells, using AZI1 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using AZI1 Polyclonal Antibody

Anti-CEP131 antibody (311-360 aa) (STJ91793)

SKU:
STJ91793

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Centrosomal protein of 131 kDa (311-360 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CEP131
Gene ID: 22994
Uniprot ID: CP131_HUMAN
Immunogen Region: 311-360 aa
Specificity: AZI1 Polyclonal Antibody detects endogenous levels of AZI1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human AZI1 at the amino acid range 311-360
Function Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner. Acts also as a negative regulator of BBSome ciliary trafficking. Plays a role in sperm flagellar formation.may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail. Required for optimal cell proliferation and cell cycle progression.may play a role in the regulation of genome stability in non-ciliogenic cells. Involved in centriole duplication. Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2. Essential for maintaining proper centriolar satellite integrity.
Protein Name Centrosomal Protein Of 131 Kda
5-Azacytidine-Induced Protein 1
Pre-Acrosome Localization Protein 1
Database Links Reactome: R-HSA-2565942
Reactome: R-HSA-380259
Reactome: R-HSA-380270
Reactome: R-HSA-380284
Reactome: R-HSA-380320
Reactome: R-HSA-5620912
Reactome: R-HSA-8854518
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Centriolar Satellite
Centriole
Cilium Basal Body
Cytoplasmic Vesicle
Secretory Vesicle
Acrosome
Colocalized With Pericentriolar Material Protein Pcm1 At Centriolar Satellites
During Spermiogenesis
Becomes Enriched With Nephrocystin Nphp1 At The Transition Zone
A Structure At The Base Of The Ciliary Axoneme Important For Regulating Traffic Into The Ciliary Compartment
Traffics Towards And Away From The Centrosome/Basal Body And The Transition Zone Of The Ciliary Axoneme In A Microtubule-Dependent Manner
Localized At The Golgi-Derived Acrosome And The Centrosome-Containing Head-Tail Coupling Apparatus (Htca)
Ubiquitinated Form Is Sequestered And Colocalized With Bbs4
Cep290
Pcm1 And Pcnt At Centriolar Satellites In Proliferating Cells
Colocalized With The Pericentriolar Material Protein Pcm1 At Centrosome
Traffics Towards And Away From Centriolar Satellites And Centrosome In A Microtubule- And Dynein-Dependent Manner In Interphase Cells
Displaced From Centriolar Satellites But Still Remains Associated With The Centrosome In Response To Cellular Stress
Such As Ultraviolet Light (Uv) Radiation Or Heat Shock
In A Process That Requires P38 Mapk Signaling
Alternative Antibody Names Anti-Centrosomal Protein Of 131 Kda antibody
Anti-5-Azacytidine-Induced Protein 1 antibody
Anti-Pre-Acrosome Localization Protein 1 antibody
Anti-CEP131 antibody
Anti-AZI1 antibody
Anti-KIAA1118 antibody

Information sourced from Uniprot.org

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