| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Centromere protein I (10-90 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CENPI |
| Gene ID: | 2491 |
| Uniprot ID: | CENPI_HUMAN |
| Immunogen Region: | 10-90 aa |
| Specificity: | CENPI Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 10-90 |
| Function | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone. |
| Protein Name | Centromere Protein I Cenp-I Fsh Primary Response Protein 1 Follicle-Stimulating Hormone Primary Response Protein Interphase Centromere Complex Protein 19 Leucine-Rich Primary Response Protein 1 |
| Database Links | Reactome: R-HSA-141444 Reactome: R-HSA-2467813 Reactome: R-HSA-2500257 Reactome: R-HSA-5663220 Reactome: R-HSA-606279 Reactome: R-HSA-68877 Reactome: R-HSA-9648025 |
| Cellular Localisation | Nucleus Chromosome Centromere Localizes Exclusively In The Centromeres The Cenpa-Cad Complex Is Probably Recruited On Centromeres By The Cenpa-Nac Complex |
| Alternative Antibody Names | Anti-Centromere Protein I antibody Anti-Cenp-I antibody Anti-Fsh Primary Response Protein 1 antibody Anti-Follicle-Stimulating Hormone Primary Response Protein antibody Anti-Interphase Centromere Complex Protein 19 antibody Anti-Leucine-Rich Primary Response Protein 1 antibody Anti-CENPI antibody Anti-FSHPRH1 antibody Anti-ICEN19 antibody Anti-LRPR1 antibody |
Information sourced from Uniprot.org