Anti-CENPC antibody (1-300) (STJ28640)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CENPC (1-300) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CENPC |
| Gene ID | 1060 |
| Uniprot ID | CENPC_HUMAN |
| Immunogen Region | 1-300 |
| Immunogen Sequence | MAASGLDHLKNGYRRRFCRP SRARDINTEQGQNVLEILQD CFEEKSLANDFSTNSTKSVP NSTRKIKDTCIQSPSKECQK SHPKSVPVSSKKKEASLQFV VEPSEATNRSVQAHEVHQKI LATDVSSKNTPDSKKISSRN INDHHSEADEEFYLSVGSPS VLLDAKTSVSQNVIPSSAQK RETYTFENSVNMLPSSTEVS VKTKKRLNFDDKVMLKKIEI DNKVSDEEDKTSEGQERKP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CENPC (NP_001803.2). |
Additional Info
| Function | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. |
| Protein Name | Centromere Protein CCenp-CCentromere Autoantigen CCentromere Protein C 1Cenp-C 1Interphase Centromere Complex Protein 7 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-606279Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreLocalizes Exclusively In The Kinetochore Domain Of Centromeres |
| Alternative Antibody Names | Anti-Centromere Protein C antibodyAnti-Cenp-C antibodyAnti-Centromere Autoantigen C antibodyAnti-Centromere Protein C 1 antibodyAnti-Cenp-C 1 antibodyAnti-Interphase Centromere Complex Protein 7 antibodyAnti-CENPC antibodyAnti-CENPC1 antibodyAnti-ICEN7 antibody |
Information sourced from Uniprot.org