Anti-Cenexin1 antibody [R09-7L3] (STJA0036841)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human Cenexin1/ODF2
General Information
| Short Description | Rabbit monoclonal anti-Cenexin1 for use in WB and FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/FC |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R09-7L3 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000FC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | ODF2 |
| Gene ID | 4957 |
| Uniprot ID | ODFP2_HUMAN |
| Immunogen | A synthesized peptide derived from human Cenexin1/ODF2 |
Additional Info
| Tissue Specificity | Testis-specific (at protein level). Highly expressed in cytoplasm of step 2 round spermatids. Detected in the middle piece and extends to about half the principal piece of the sperm tails. |
| Post Translational Modifications | Tyrosine phosphorylated. Phosphorylated by TSSK4 on Ser-95. |
| Function | Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly. |
| Protein Name | Outer Dense Fiber Protein 2CenexinOuter Dense Fiber Of Sperm Tails Protein 2 |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCell ProjectionCiliumCentrioleSpindle PoleFlagellumLocalized At The Microtubule Organizing Centers In Interphase And Spindle Poles In MitosisLocalized At The Distal/Subdistal Appendages Of Mother Centrioles |
| Alternative Antibody Names | Anti-Outer Dense Fiber Protein 2 antibodyAnti-Cenexin antibodyAnti-Outer Dense Fiber Of Sperm Tails Protein 2 antibodyAnti-ODF2 antibody |
Information sourced from Uniprot.org