Anti-CEMIP antibody [SAA1707] (STJA0020135)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Cell Migration-Inducing And Hyaluronan-Binding Protein antibody for use in ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1707 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | CEMIP |
| Gene ID | 57214 |
| Uniprot ID | CEMIP_HUMAN |
Additional Info
| Post Translational Modifications | N-glycosylated.glycosylation is not necessary for HA-binding. |
| Function | Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing. |
| Protein Name | Cell Migration-Inducing And Hyaluronan-Binding ProteinHyaluronan Binding Protein Involved In Hyaluronan Depolymerization |
| Database Links | Reactome: R-HSA-2142850 |
| Cellular Localisation | NucleusCytoplasmEndoplasmic ReticulumCell MembraneMembraneClathrin-Coated PitSecretedRetained In The Endoplasmic Reticulum (Er) In A Hspa5/Bip-Dependent MannerColocalized With Clathrin Heavy Chain/Cltc In Clathrin-Coated VesiclesStrongly Detected In The Cytoplasm Of Breast Carcinoma CellsWhereas Poorly Detected In Adjacent Normal Epithelial CellsStromal CellsOr Benign Breast TissuesLocalized In The Nucleus And Cytoplasm Of Colon Adenocarcinomas |
| Alternative Antibody Names | Anti-Cell Migration-Inducing And Hyaluronan-Binding Protein antibodyAnti-Hyaluronan Binding Protein Involved In Hyaluronan Depolymerization antibodyAnti-CEMIP antibodyAnti-HYBID antibodyAnti-KIAA1199 antibody |
Information sourced from Uniprot.org