Anti-Cellubrevin antibody [R08-3P3] (STJA0036877)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human Cellubrevin
General Information
| Short Description | Rabbit monoclonal anti-Cellubrevin for use in WB, ICC, IF, IP and FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF/IP/FC |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R08-3P3 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200IP 1:40FC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | VAMP3 |
| Gene ID | 9341 |
| Uniprot ID | VAMP3_HUMAN |
| Immunogen | A synthesized peptide derived from human Cellubrevin |
Additional Info
| Post Translational Modifications | Ubiquitinated by RNF167 at Lys-66, Lys-68 and Lys-77, regulating the recycling endosome pathway. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which hydrolyzes the 59-Gln-|-Phe-60 bond and probably inhibits neurotransmitter release. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which hydrolyzes the 42-Lys-|-Leu-43 bond and probably inhibits neurotransmitter release. Note that humans are not known to be infected by C.botulinum type D. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which hydrolyzes the 41-Gln-|-Lys-42 bond and probably inhibits neurotransmitter release. |
| Function | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. |
| Protein Name | Vesicle-Associated Membrane Protein 3Vamp-3CellubrevinCebSynaptobrevin-3 |
| Database Links | Reactome: R-HSA-1236974Reactome: R-HSA-6811440Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013406Reactome: R-HSA-9013407Reactome: R-HSA-9013408Reactome: R-HSA-9013409Reactome: R-HSA-9013423Reactome: R-HSA-9035034 |
| Cellular Localisation | Early Endosome MembraneSingle-Pass Type Iv Membrane ProteinRecycling Endosome MembraneSynapseSynaptosome |
| Alternative Antibody Names | Anti-Vesicle-Associated Membrane Protein 3 antibodyAnti-Vamp-3 antibodyAnti-Cellubrevin antibodyAnti-Ceb antibodyAnti-Synaptobrevin-3 antibodyAnti-VAMP3 antibodyAnti-SYB3 antibody |
Information sourced from Uniprot.org