| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CELF2 (422-521) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CELF2 |
| Gene ID: |
10659 |
| Uniprot ID: |
CELF2_HUMAN |
| Immunogen Region: |
422-521 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 422-521 of human CELF2 (NP_006552.3). |
| Immunogen Sequence: |
QQSAAGSQKEGPEGANLFIY HLPQEFGDQDILQMFMPFGN VISAKVFIDKQTNLSKCFGF VSYDNPVSAQAAIQAMNGFQ IGMKRLKVQLKRSKNDSKPY |
| Tissue Specificity | Expressed in frontal cortex. Isoform 1 is expressed in brain and lung. Isoform 2 is expressed in heart, brain, placenta, lung, liver, kidney, skeletal muscle and pancreas. Isoform 4 is expressed in heart, lung, skeletal muscle, kidney and pancreas. |
| Function | RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury. Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediately upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA. Binds to an intronic RNA element responsible for the silencing of exon 21 splicing. Binds to (CUG)n repeats. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA. |
| Protein Name | Cugbp Elav-Like Family Member 2Celf-2Bruno-Like Protein 3Cug Triplet Repeat Rna-Binding Protein 2Cug-Bp2Cug-Bp- And Etr-3-Like Factor 2Elav-Type Rna-Binding Protein 3Etr-3Neuroblastoma Apoptosis-Related Rna-Binding ProteinHnaporRna-Binding Protein Brunol-3 |
| Cellular Localisation | NucleusCytoplasmAccumulates In The Cytoplasm After Ionizing RadiationColocalizes With Apobec1 And A1cfRna-Binding Activity Is Detected In Both Nuclear And Cytoplasmic Compartments |
| Alternative Antibody Names | Anti-Cugbp Elav-Like Family Member 2 antibodyAnti-Celf-2 antibodyAnti-Bruno-Like Protein 3 antibodyAnti-Cug Triplet Repeat Rna-Binding Protein 2 antibodyAnti-Cug-Bp2 antibodyAnti-Cug-Bp- And Etr-3-Like Factor 2 antibodyAnti-Elav-Type Rna-Binding Protein 3 antibodyAnti-Etr-3 antibodyAnti-Neuroblastoma Apoptosis-Related Rna-Binding Protein antibodyAnti-Hnapor antibodyAnti-Rna-Binding Protein Brunol-3 antibodyAnti-CELF2 antibodyAnti-BRUNOL3 antibodyAnti-CUGBP2 antibodyAnti-ETR3 antibodyAnti-NAPOR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
