Anti-CEACAM6 antibody (35-320) [S4910RM] (STJ11104910)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Carcinoembryonic antigen-Related Cell Adhesion Molecule 6 (35-320) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S4910RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CEACAM6 |
| Gene ID | 4680 |
| Uniprot ID | CEAM6_HUMAN |
| Immunogen Region | 35-320 |
| Immunogen Sequence | KLTIESTPFNVAEGKEVLLL AHNLPQNRIGYSWYKGERVD GNSLIVGYVIGTQQATPGPA YSGRETIYPNASLLIQNVTQ NDTGFYTLQVIKSDLVNEEA TGQFHVYPELPKPSISSNNS NPVEDKDAVAFTCEPEVQNT TYLWWVNGQSLPVSPRLQLS NGNMTLTLLSVKRNDAGSYE CEIQNPASANRSDPVTLNVL YGPDVPTISPSKANYRPGEN LNLSCHAASNPPAQYSWFI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 35-320 of human CEACAM6 (NP_002474.4). |
Additional Info
| Tissue Specificity | Expressed in neutrophils. Expressed in columnar epithelial and goblet cells of the colon. Expressed in numerous tumor cell lines (at protein level). |
| Post Translational Modifications | Glycosylated. |
| Function | Cell surface glycoprotein that plays a role in cell adhesion and tumor progression. Intercellular adhesion occurs in a calcium- and fibronectin-independent manner. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8. Heterophilic interaction with CEACAM8 occurs in activated neutrophils. Plays a role in neutrophil adhesion to cytokine-activated endothelial cells. Plays a role in cell migration and cell adhesion to endothelial cells. |
| Protein Name | Cell Adhesion Molecule Ceacam6Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6Cea Cell Adhesion Molecule 6Non-Specific Crossreacting AntigenNormal Cross-Reacting AntigenCd Antigen Cd66c |
| Database Links | Reactome: R-HSA-1566977Reactome: R-HSA-202733Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorApical Cell MembraneCell SurfaceLocalized To The Apical Glycocalyx Surface |
| Alternative Antibody Names | Anti-Cell Adhesion Molecule Ceacam6 antibodyAnti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 antibodyAnti-Cea Cell Adhesion Molecule 6 antibodyAnti-Non-Specific Crossreacting Antigen antibodyAnti-Normal Cross-Reacting Antigen antibodyAnti-Cd Antigen Cd66c antibodyAnti-CEACAM6 antibodyAnti-NCA antibody |
Information sourced from Uniprot.org